Polymarket is leveraging fantasy sports leader PrizePicks’ user base and regulatory standing as its gateway to re-entering the U.S. market. Summary Polymarket has partnered with fantasy sports leader PrizePicks to re-enter the U.S. market through a regulated framework. The platform will also work with DraftKings, positioning itself as core infrastructure for prediction markets. According to a prepared statement on Nov. 11, PrizePicks will integrate Polymarket’s event contracts into its own platform, offering its users access to a new class of predictions on sports, entertainment, and cultural events. The deal comes as Polymarket, long viewed as a bellwether for prediction trading, prepares for its regulated return to the U.S. following the acquisition of QCEX, an exchange and clearinghouse, earlier this year. “PrizePicks has built one of the nation’s most exciting sports communities, and we are excited to help bring prediction markets into that world,” Polymarket CEO Shayne Coplan said. “As we prepare to return to the U.S., this partnership shows how prediction markets can enhance fandom while setting a new standard for interactive, regulated sports engagement.” Prediction markets go mainstream According to Bloomberg, Polymarket is preparing a return to the U.S. later this month, marking its first regulated domestic entry since it began blocking U.S. users in 2022 as part of a settlement with the CFTC. Its partnership with PrizePicks gives the New York-based firm an immediate foothold among millions of active U.S. fantasy sports users while easing regulatory friction through an already-licensed operator. Notably, the company isn’t stopping with PrizePicks. Polymarket is also preparing to serve as the designated clearinghouse for DraftKings’ upcoming predictions product, according to remarks made by DraftKings CEO Jason Robins during the firm’s latest earnings call. This dual approach with two major players signals a deliberate strategy to become the indispensable infrastructure layer powering prediction markets across the entire sector, positioning Polymarket as a wholesale provider to retail giants. The aggressive expansion comes amid a period of staggering growth for the platform. Polymarket claims billions of dollars in prediction volume have been traded on its platform in 2025 alone. This activity has attracted significant institutional capital, including a strategic investment of up to $2 billion from the Intercontinental Exchange, the parent company of the New York Stock Exchange. The timing of this expansion is no coincidence. The predictions sector is in the midst of a broader boom, with exchanges and social platforms rushing to capture retail demand for event-based speculation. Trump Media, for instance, plans to launch “Truth Predict,” a regulated predictions platform integrated into its Truth Social network. Powered by Crypto.com’s CFTC-registered derivatives exchange, the feature will allow users to trade contracts tied to elections, economic data, and sports outcomes.
